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For example, a decision about the accuracy of a diagnostic test is best informed by evidence from a cross-sectional study, not a RCT. A cohort study, not a RCT, best answers a question about prognosis. However, in selecting a treatment, the RCT is the best study design to provide the most accurate estimate of treatment efficacy and safety. com. Copyright © 2008, 2005, 2002 by The McGraw-Hill Companies, Inc. Click here for terms of use. This page intentionally left blank C HAP T E R 4 KEY CONCEPTS ᕡ Documentation of pharmacists’ interventions, their actions, and the impact on patient outcomes is central to the process of pharmaceutical care.

The value of the volume of distribution is determined by the physiologic volume of blood and tissues and how the drug binds in blood and tissues. ᕤ Half-life is the time required for serum concentrations to decrease by one-half after absorption and distribution are complete. Half-life is important because it determines the time required to reach steady state and the dosage interval. Half-life is a dependent kinetic variable because its value depends on the values of clearance and volume of distribution.

These texts are intended to meet the needs of additional audiences, including nurse practitioner and physician assistant programs and practicing primary care physicians, nurse practitioners, and physician assistants. The Online Learning Center continues to provide unique features designed to benefit students, practitioners, and faculty around the world. The site includes learning objectives and self-assessment questions for each chapter, and the full text of this Copyright © 2008, 2005, 2002 by The McGraw-Hill Companies, Inc.

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Cryophysics (Interscience tracts on physics and astronomy) by K Mendelssohn


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