By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)
This publication presents an creation to marrow and peripheral blood stem phone transplantation (including wire blood transplants), emphasizing the foundations of this speedily evolving zone. a quick old point of view is given and the newest advancements are mentioned. specific realization is given to the explanation and symptoms for transplantation, the choice of donors and resource of stem cells, and the separation, enlargement and manipulation of stem cells. crucial points of histocompatibility, preparative regimens utilized in stem cellphone transplantation, using hematopoietic development components and cytokines, the pathophysiology of the graft-versus-host response, and the administration of problems are handled. This booklet should still give you the practising internist, pediatrician, hematologist, and oncologist in addition to different physicians in education or in perform, physicians' assistants, nurses, and scholars with the knowledge essential to comprehend the suggestions of stem cellphone transplantation and to incorporate transplantation within the therapy making plans quickly after a prognosis has been proven. The textual content must also be helpful to the health care provider who resumes the sufferers' care after they go back from the transplant center.
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Additional resources for A Guide to Blood and Marrow Transplantation
Organ Function Screening A previous history of cardiac, pulmonary, renal, hepatic or endocrine disease must be solicited, as underlying disease in these organs may complicate or even contraindicate transplantation. It is important to emphasize that pre-transplant impairment may be subclinical or subtle, only to become manifest after the "stress" of the conditioning regimen or other elements of the transplant. Systematic laboratory evaluation of heart, lung, kidney, liver and certain endocrine gland functions should be performed.
Minor donors requires special consideration. In many cases, a potential donor may not feel he or she has any real choice regarding participation in the transplant because it has been taken for granted that they will donate. Such an assumption should not be made; a potential donor who is fully informed and truly does not wish to donate should be firmly supported in this decision. A candid discussion acknowledging the common and at times conflicting emotions reported by donors (such as the chance to help someone else, fear of "failure" of the transplant, sense of responsibility for engraftment and/or GVHD) may help alleviate to some extent the anxiety experienced by donors.
Transfusions, including number, type, results, reactions 8. Psychological assessment, with special attention to understanding of the procedure B. Full discussion of stem cell transplantation, including its rationale, risks and benefits with the patient, donor, other family and referring physician. ) C. Histocompatibility testing for allogeneic stem cell transplantation 1. Serologic typing on patient and members of the nuclear (or extended) family or unrelated donors 2. Molecular studies as required D.
A Guide to Blood and Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)